https://www.ceesdekker.net - An Overview

https://www.ceesdekker.net - An Overview

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‘The second is nanopores, which can be our oldest line of analysis and which has now led to DNA sequencers according to nanopores. We pull person DNA strands through a nanopore and will then study off the nucleotide sequence. Very recently, we even managed to read out only one protein for The 1st time working with This method. But this line of analysis is not just about developing applications, but will also about authentic biological questions.

Human Rad51 filaments on double- and solitary-stranded DNA: correlating frequent and irregular types with recombination purpose.

Multicolor imaging of the bacterial nucleoid and mobile division proteins with blue, orange, and in close proximity to-infrared fluorescent proteins

A rhythmically pulsing leaf-spring DNA-origami nanoengine that drives a passive follower Mathias Centola

2012, discovery that nucleoid occlusion underlies the precision of bacterial mobile division; and very first at any time research from the dynamics DNA supercoils and the discovery of supercoil hopping

Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes

Several relevant developments followed, the place our group proven diverse transistor variants for example solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into compact evidence-of-basic principle Digital circuits.

Studying DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.

2003, shown the main biosensors designed away from a carbon nanotube; solved the framework and mechanism of DNA restore proteins; and discovery of a new system for fabricating stable-condition nanopores for DNA translocation

Bulk-surface coupling identifies the mechanistic relationship concerning Min-protein styles in vivo As well as in vitro

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Cees Dekker is Distinguished University Professor at TU Delft. Trained to be a physicist, he pioneered nanotechnology with quite a few discoveries on carbon nanotubes while in the nineties. Given that 2000, he moved to single-molecule biophysics and nanobiology. His current investigate focuses on (i) nanopores for protein sequencing; (ii) chromosome structure, especially SMC motor protein; and (iii) creating a living artificial cell from lifeless molecules. Dekker can be an elected member with the KNAW and fellow for the APS and the IOP.

2008, very first observation of protein-coated DNA translocation by means of nanopores; settled the origin from the electrophoretic force on DNA in nanopores; found a significant velocity increase of microtubules in electric powered fields; learned an anomalous electro-hydrodynamic orientation of microtubules; and solved the origin of sound in carbon nanotubes in liquid

2013, controlled shaping of live bacterial cells into arbitrary designs; and discovery of spontaneous https://www.ceesdekker.net fluctuations in the handedness of histone tetrasomes